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Results for "

Salt-inducible Kinase (SIK)

" in MedChemExpress (MCE) Product Catalog:

14

Inhibitors & Agonists

1

Peptides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P1576A
    AMARA peptide TFA

    		Salt-inducible Kinase (SIK) AMPK Others
    AMARA peptide (TFA) is a substrate for salt-inducible kinase (SIK) and adenosine monophosphate activated protein kinase (AMPK).
    AMARA peptide TFA
  • HY-139253
    MRIA9

    		Salt-inducible Kinase (SIK) PAK Apoptosis Cancer
    MRIA9 is an ATP-competitive, pan Salt-Inducible kinase (SIK) and PAK2/3 inhibitor, with IC50 values of 516 nM, 180 nM and 127 nM for SIK1, SIK2 and SIK3, respectively .
    MRIA9
  • HY-15776
    HG-9-91-01
    Maximum Cited Publications
    22 Publications Verification

    SIK inhibitor 1

    		 Salt-inducible Kinase (SIK) Inflammation/Immunology
    HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIK) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively.
    HG-9-91-01
  • HY-129141
    YKL-06-062

    		Salt-inducible Kinase (SIK) Inflammation/Immunology
    YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor with an IC50 of 2.12 nM/1.40 nM/2.86 nM for SIK1, SIK2 and SIK3, respectively .
    YKL-06-062
  • HY-138001
    WH-4-025

    		Salt-inducible Kinase (SIK) Cancer
    WH-4-025 is a Salt-inducible kinase (SIK) inhibitor (WO2016023014 A2) .
    WH-4-025
  • HY-120856
    ARN-3236
    3 Publications Verification

    		 Salt-inducible Kinase (SIK) Inflammation/Immunology Cancer
    ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), with IC50s of <1 nM, 21.63 nM and 6.63 nM for SIK2, SIK1 and SIK3, respectively. Has anti-cancer activity .
    ARN-3236
  • HY-120056
    YKL-06-061
    2 Publications Verification

    		 Salt-inducible Kinase (SIK) Inflammation/Immunology
    YKL-06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively .
    YKL-06-061
  • HY-101147
    YKL-05-099
    3 Publications Verification

    		 Salt-inducible Kinase (SIK) Inflammation/Immunology
    YKL-05-099 is a salt-inducible kinase (SIK) inhibitor. YKL-05-099 binds to SIK1 and SIK3 with IC50s of ~10 and ~30 nM, respectively. YKL-05-099 has slightly less potent SIK2-inhibitory (IC50=40 nM) .
    YKL-05-099
  • HY-N1570
    Pterosin B

    Pterosin B, a indanone found in bracken fern (Pteridium aquilinum), is an inhibitor of salt-inducible kinase 3 (Sik3) signaling. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3 .
    Pterosin B
  • HY-149075
    MR22

    		Salt-inducible Kinase (SIK) Cancer
    MR22 is a potent pan-SIK (salt-inducible kinase) inhibitor. MR22 no longer exhibits activity on STE group kinases and displays excellent selectivity in a representative kinase panel. MR22-dependent SIK inhibition led to centrosome dissociation and subsequent cell-cycle arrest in ovarian cancer cells .
    MR22
  • HY-161440
    SIK-IN-1

    		AMPK Inflammation/Immunology
    SIK-IN-1 (Compound 53) is an inhibitor for salt-inducible kinase (SIK), which inhibits SKI1, SIK2 and SIK3 with IC50s of 0.1, 0.4 and 1.5 nM, respectively. SIK-IN-1 inhibits the release of TNFa with IC50 of 0.5 nM, stimulates the LPS (HY-D1056) -induced IL-10 release with EC50 of 4 nM in human macrophages .
    SIK-IN-1
  • HY-161441
    SIK-IN-2

    		AMPK Inflammation/Immunology
    SIK-IN-2 (Compound 45) is an inhibitor for salt-inducible kinase (SIK), which inhibits SKI1, SIK2 and SIK3 with IC50s of 0.1, 0.2 and 0.4 nM, respectively. SIK-IN-2 inhibits the release of TNFa with IC50 of 0.5 nM, stimulates the LPS (HY-D1056) -induced IL-10 release with EC50 of 2 nM in human macrophages .
    SIK-IN-2
  • HY-161442
    SIK-IN-3

    		AMPK Inflammation/Immunology
    SIK-IN-3 (Compound 6B) is an inhibitor for salt-inducible kinase (SIK), which inhibits SKI1, SIK2 and SIK3 with IC50s of 0.1, 0.3 and 0.8 nM, respectively. SIK-IN-1 inhibits the release of TNFa with IC50 of 0.6 nM, stimulates the LPS (HY-D1056) -induced IL-10 release with EC50 of 3 nM in human macrophages .
    SIK-IN-3
  • HY-149365
    SIKs-IN-1

    		Salt-inducible Kinase (SIK) Inflammation/Immunology
    SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, is a Salt-inducible kinases (SIKs) inhibitor. SIKs regulates the transformation of M1/M2 macrophages, involving in inflammation process. SIKs-IN-1 inhibits SIK activity, up-regulates anti-inflammatory cytokine IL-10, but down-regulates pro-inflammatory cytokine IL-12. SIKs-IN-1 shows excellent anti-inflammatory effects in a DSS-induced colitis model .
    SIKs-IN-1

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